Publications 2001 – 2010

Publications 2010

Eide MB, Liestøl K, Lingjærde OC, Hystad M, Kresse SH, Meza-Zepeda L, Myklebost O, Aamot HV, Holte H, Smeland EB, Delabie J (2010) DNA copy number alterations reveal potential for higher grade transformation in Follicular lymphoma and confirm parallel evolution of tumor cell clones. Blood doi:10.1182/blood-2010-03-272278 PDF

Henriksen J, Stabell M, Meza-Zepeda LA, Lauvrak SAU, Kassem M, Myklebost O (2010) Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells BMC Cancer, 10:329 PDF 

Kresse SH, Szuhai K, Barragan-Polania A, Rydbeck H, Cleton-Jansen AM, Myklebost O, Meza-Zepeda LA (2010) Evaluation of high-resolution microarray platforms for genomic profiling of bone tumours BMC Research Notes 3:223 PDF 

Kresse SH, Ohnstad HO, Bjerkehagen B, Myklebost O, Meza-Zepeda LA (2010) DNA Copy Number Changes in Human Malignant Fibrous Histiocytomas by Array Comparative Genomic Hybridisation PloS One Nov 9;5:e15378 PDF

Mayordomo E, Machado I, Giner F, Kresse SH, Myklebost O, Carda C, Navarro S, Llombart-Bosch (2010) A Histopathology, immunohistochemistry and xenotransplant in Osteosarcoma: a tissue microarray study. Applied Immunohistochemistry and Molecular Morphology doi: 10.1097/PAI.0b013e3181daace3 PDF

Ottaviano L, Schaefer KL, Gajewski M, Huckenbeck W, Baldus S, Rogel U, Mackintosh C, de Alava E, Myklebost O, Kresse SH, Meza-Zepeda LA, Serra M, Cleton-Jansen AM, Hogendoorn PCW, Buerger H, Gabbert HE, Poremba C (2010) Molecular characterization of commonly used cell lines for bone tumor research. A trans-European EuroBoNet effort. Genes Chromosomes Cancer 49:40-51 PubMed

Müller CR, Namløs H, Smeland S, Sæter G, Bjerkehagen B, Bjerner J, Holden M, Bruland Ø, Myklebost O (2010)Characterization of Treatment Response to Interferon-a in Osteosarcoma Xenografts. J Cancer Sci Ther 2:33-42 PDF

Skårn M, Namløs HM, Noordhuis P, Meng-Yu Wang, Meza-Zepeda LA, Myklebost O (2010) Adipocyte Differentiation of Immortalized Human Bone Marrow-Derived Stromal Cells is Modulated by microRNA-155, microRNA-221 and microRNA-222 Stem Cells and Development PDF ahead of print

Tenstad E, Tourovskaia A, Folch A, Myklebost O, Rian E (2010) Extensive adipogenic and osteogenic differentiation of patterned human mesenchymal stem cells in a microfluidic device. Lab on a Chip  DOI:10.1039/B926738G PDF see special mention Cover page 

Publications 2009

Kresse SH, Ohnstad HO, Paulsen EB, Bjerkehagen B, Szuhai K, Serra M, Schaefer K-L, Myklebost O, Meza-Zepeda LA (2009) LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas identified by array comparative genomic hybridization. Genes Chromosomes Cancer 48 (8), 679-93 PubMed 19441093

Lehne G, Grasmo-Wendler UH, Berner JM, Meza-Zepeda LA, Adamsen BL, Flack A, Reiner A, Clausen OPF, Hovig E, Myklebost O (2009). Upregulation of stem cell genes in multidrug resistant K562 leukem ia cells. Leukemia Research  33 (10), 1379-85 PubMed 19394083

Revheim ME, Seierstad T, Berner JM, Bruland OS, Roe K, Ohnstad HO, Bjerkehagen B, Bach-Gansmo T. 2009. Establishment and characterization of a human gastrointestinal stromal tumour (GIST) xenograft in athymic nude mice. Anticancer Res 29:4331-6

Våtsveen TK, Tian E, Kresse SH, Meza-Zepeda LA, Gabrea A, Glebov O, Dai HY, Sundan A, Kuehl WM, Børset M (2009) OH-2, a hyperdiploid myeloma cell line without an IGH translocation, has a complex translocation juxtaposing MYC near MAFB and the IGK locus. Leukemia Research 33:1670 PubMed 19395026

Publications 2008

Kresse SH, Skårn M, Ohnstad HO, Namløs HM, Bjerkehagen B, Wang J, Myklebost O and Meza-Zepeda LA. (2008) DNA copy number changes in malignant peripheral nerve sheath tumors by array comparative genomic hybridization. Molecular Cancer 7:48 PDF

Larsen E, Kleppa L, Meza TJ, Meza-Zepeda LA, Rada C, Castellanos CG, Lien GF, Nesse GJ, Neuberger MS, Laerdahl JK, Doughty RW, Klungland A (2008) Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants Cancer Res68:4571-9 PDF

Lybæk H, Meza-Zepeda LA, Kresse SH, Høysæter T, Steen VM, Houge G. (2008) Array-CGH fine mapping of minor and cryptic chromosome-CGH detected genomic imbalances in 80 out of 590 patients abnormal development. Eur j Hum Genet 16:1318-28

Lyng H, Lando M, Brøvig RS, Svendsrud DH, Johansen M, Galteland E, Brustugun OT, Meza-Zepeda LA, Myklebost O, Kristensen GB, Hovig E, Stokke T (2008) GeneCount: Genome-wide calculation of absolute tumor DNA copy numbers from array CGH data Genome Biology 2008, 9:R86 PDF

Meza-Zepeda LA, Noer A, Dahl JA, Micci F, Myklebost O, Collas P (2008) High-resolution analysis of genetic stability of human adipose tissue stem cells cultured to senescence. J Cell Mol Med 12:553-63 PDF

Nakajima G, Patino-Garcia A, Bruheim S, Xi Y, San Julian M, Lecanda F, Sierrasesumaga L, Müller C, Fodstad O, Ju J(2008)
CDH11 expression is associated with survival in patients with osteosarcoma Cancer Genomics Proteomics, 5 (1), 37-42
PubMed 18359978

Roman E, Meza-Zepeda LA, Kresse SH, Myklebost O, Vasstrand EN, Ibrahim SO (2008) Chromosomal aberrations in head and neck squamous cell carcinomas in Norwegian and Sudanese populations by array comparative genomic hybridization. Oncol Rep 20:825-43 PDF

Varghese M, Olstorn H, Sandberg C, Vik-Mo EO, Noordhuis P, Nistér M, Berg-Johnsen J, Moe MC, Langmoen IA (2008) A comparison between stem cells from the adult human brain and from brain tumors. Neurosurgery. 2008 Dec;63(6):1022-33; discussion 1033-4

Publications 2007

Kleivi K, Lind GE, Diep CB, Meling GI, Brandal LT, Nesland JM, Myklebost O, Rognum TO, Giercksky KE, Skotheim RI, Lothe RA (2007) Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses. Molecular Cancer 6:2 PDF

Müller CR, Paulsen EB, Noordhuis P, Peudeutour F, Sæter G, Myklebost O (2007) Potential For Treatment Of Liposarcomas With The MDM2 Antagonist Nutlin-3a In J Cancer 121: 199-205 PDF

Princy Francis, Heidi Maria Namløs, Christoph Müller, Patrik Edén, Josefin Fernebro, Jeanne-Marie Berner, Bodil Bjerkehagen, Måns Åkerman, Pär-Ola Bendahl, Anna Isinger, Anders Rydholm, Ola Myklebost and Mef Nilbert (2007) Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential BMC Genomics 2007, 8:73 PDF

Cekaite L, Peng Q, Reiner A, Shahzidi S, Tveito S, Furre IE, Hovig E (2007) Mapping of oxidative stress responses of human tumor cells following photodynamic therapy using hexaminolevulinate BMC Genomics 8:273 PDF

Publications 2006

Berner JM, Müller CR, Holden M, Wang J, Hovig E, Myklebost O (2006) Sampling effects on gene expression data from a human tumor xenograft Scand J Lab Animal Science 33:17-30 PDF

Meza-Zepeda LA, Kresse SH, Barragan-Polania AHB
, Bjerkehagen B, Ohnstad HO, Namløs HM, Wang J, Kristiansen BE, Myklebost O (2006) Array CGH unveils distinct DNA copy number differences between leiomyosarcomas and gastrointestinal stromal tumours Cancer Research 66:8984-93

Sivertsen EA, Galteland E, Mu D, Holte H, Meza-Zepeda L, Myklebost O, Patzke S, Smeland EB, Stokke T (2006) gain of chromosome 6p is an infrequent cause of increased PIM1 expression in B-cell non-Hodgkin’s lymphomas. Leukaemia 20:539-542

The MAQC Consortium [including Myklebost O] (2006) The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements Nature Biotech Vol 24: pp1151 – 1161

Tovar C, Rosinski J, Filipovic Z, Higgins B, Kolinsky K, Hilton H, Zhao X, Vu BT, Qing W, Packman K, Myklebost O, Heimbrook DC, Vassilev LT (2006) Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy Proc Natl Acad Sci USA 103:188-1893 PDF See Editorial in PNAS.

Publications 2005

Bjerkehagen B, Myklebost O (2005) Diagnostisk Molekylærbiologi: Ben- og bløtvevsvulster. Tidsskr. Nor. Lægeforening 125: 3286-9 PDF

Dietze A, Peng Q, Selbo PK, Kaalhus O, Müller C, Bown S, Berg K (2005) Enhanced photodynamic destruction of a transplantable fibrosarcoma using photochemical internalisation of gelonin. Br J Cancer 6:2004-9

Galteland E, Sivertsen EA, Svendsrud DH, Smedshammer L, Kresse SH, Meza-Zepeda LA, Myklebost O, Suo Z, Mu D, Deangelis PM, Stokke T. (2006) Translocation t(14;18) and gain of chromosome 18/BCL2: effects on BCL2 expression and apoptosis in B-cell non-Hodgkin’s lymphomas. Leukemia 19:2313-2323

Kresse SH, Berner JM, Meza-Zepeda LA, Gregory SG, W-L Kuo, Gray JW, Forus A Myklebost O (2005) Mapping and characterisation of the amplicon near APOA2 in 1q23 in human sarcomas Mol Cancer 2005, 4:39 PDF

Lyng H, Landsverk KS, Kristiansen E, DeAngelis P, Ree AH, Myklebost O, Hovig E, Stokke T. (2005) The response of malignant B lymphocytes to ionizing radiation: mRNA expression and genotypes. Int J Cancer 115:935-42

Dahle J, Noordhuis P, Stokke T, Svendsrud DH, Kvam E (2005) Multiplex polymerase chain reaction analysis of UV-A- and UV-B-induced delayed and early mutations in V79 Chinese hamster cells Photochem Photobiol. 81:114-9

Nygaard V, Holden M, Loland A, Langaas M, Myklebost O, Hovig E (2005) Limitations of mRNA amplification from small-size cell samples BMC Genomics 6:147 PDF

Ågesen TH, Flørenes VA, Molenaar WM, Lind GE, Berner JM, Plaat BEC, Komdeur R, Myklebost O,van den Berg E, Lothe RA (2005) Expression patterns of cell cycle components in sporadic and neurofibromatosis type 1 related malignantperipheral nerve sheath tumors. J Neuropathol Exp Neurol 64:74-81

Publications 2004

Cekaite L, Haug O, Myklebost O, Aldrin M, Østenstad B, Holden M, Frigessi A, Hovig E, Sioud M (2004) Analysis of the humoral immune response to immunoselected phagedisplayed peptides by a microarray-based method. Proteomics 4:2572-2582

Lyng H, Baidee A, Svendsrud DH, Hovig E, Myklebost O, Stokke T (2004) Profound influence of non-linearity in microarray scanners on gene expression ratios: Analysis and procedure for correction. BMC Genomics 5:10. PDF

Myklebost O (2004) Putting Norway on the gene-therapy map. Letter to the Editor of Nature 429:129. PDF

Nilbert M, Meza-Zepeda LA, Francis P, Berner JM, Namløs HM, Myklebost O (2004) Lessons from genetic profiling in soft tissue sarcomas. Acta Orth. Scand. 75 (Suppl 313) 35-50 PDF

Nilsson M, Meza-Zepeda L, Mertens M, Forus A, Myklebost O, Mandahl N.Chromosomal distribution of amplified chromosome 1 sequences in softtissue and bone tumors”. Int J Cancer 109:363-9 PDF

Trøen G, Nygaard V, Jenssen TK, Ikonomou IM, Tierens A, Matutes E, Gruszka-Westwood A, Catovsky D, Myklebost O, Lauritzsen G, Hovig E, Delabie J (2004) Constitutive expression of the AP-1 transcription factors c-jun, junD, junB and c-fos and the marginal zone B-cell transcription factor Notch2 in splenic marginal zone lymphoma. Journal of Molecular Diagnostics in press

Wang J, Meza-Zepeda LA, Kresse SH, Myklebost O (2004) M-CGH: Analysing microarray-based CGH experiments. BMC Bioinformatics 5:74 PDF

Publications 2003

Publications 2003

Andersen K, Smith-Sørensen B, Pedersen KB, Hovig E, Myklebost O, Fodstad Ø, Maelandsmo GM (2003) Interferon-gamma suppresses S100A4 transcription independently of apoptosis or cell cycle arrest Br J Cancer, 88 (12), 1995-2001
PubMed 12799648

Henriksen J, Aagesen TH, Maelandsmo GM, Lothe RA, Myklebost O, Forus A (2003) Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation Oncogene, 22 (34), 5358-61
PubMed 12917637

Maire G, Forus A, Foa C, Bjerkehagen B, Mainguené C, Kresse SH, Myklebost O, Pedeutour F (2003) 11q13 alterations in two cases of hibernoma: large heterozygous deletions and rearrangement breakpoints near GARP in 11q13.5
Genes Chromosomes Cancer, 37 (4), 389-95 PubMed 12800150

Małecki J, Wesche J, Skjerpen CS, Wiedłocha A, Olsnes S (2003) Translocation of FGF-1 and FGF-2 across vesicular membranes occurs during G1-phase by a common mechanism Mol Biol Cell, 15 (2), 801-14 PubMed 14657241

Nygaard V, Løland A, Holden M, Langaas M, Rue H, Liu F, Myklebost O, Fodstad Ø, Hovig E, Smith-Sørensen B (2003) Effects of mRNA amplification on gene expression ratios in cDNA experiments estimated by analysis of variance
BMC Genomics, 4 (1), 11 PubMed 12659661

Wang J, Bø TH, Jonassen I, Myklebost O, Hovig E (2003) Tumor classification and marker gene prediction by feature selection and fuzzy c-means clustering using microarray data BMC Bioinformatics, 4, 60 PubMed 14651757

Wang J, Myklebost O, Hovig E (2003) MGraph: graphical models for microarray data analysis Bioinformatics, 19 (17), 2210-1 PubMed 14630649

Publications 2002

Dickens DS, Kozielski R, Khan J, Forus A, Cripe TP (2002) Cyclooxygenase-2 Expression in Pediatric Sarcomas. Pediatric and Developmental Pathology 5: 356-364

Jenssen TK, Langaas M, Kuo WP, Smith-Sørensen B, Myklebost O, Hovig E (2002) Analysis of repeatability in spotted cDNA microarrays. Nucl Acids Res 30:3235-3244 Pubmed

Meza-Zepeda LA, Forus A, Lygren B, Dahlberg AB, Godager LH, South A, Maren-holtz I, Lioimi M, Flørenes VA, Mælandsmo GM, Serra M, Mischke D, Nizetic D, Ragoussis I, Tarkkanen M, Nesland J, Knuutila S, Myklebost O (2002) Positional cloning identi-fies a novel cyclophilin as a candidate amplified oncogene in 1q21. Oncogene 21:2261-9Pubmed PDF

Wang J, Nygaard V, Smith-Sørensen B, Hovig E, Myklebost O (2002) MARRAY: analysing single, replicated or reversed microarray experiments. Bioinformatics 18: 1139-40 Pubmed PDF

Wang J, Delabie J, Aasheim HC, Smeland E, Myklebost O (2002) Clustering of the SOM easily reveals distinct gene expression patterns: results of a reanalysis of lymphoma study. BMC Bioinformatics 2002 3:36 Pubmed PDF

Xie Y, Skytting B, Nilsson G, Grimer RJ, Mangham CD, Fisher C, Shipley J, Bjerkehagen B, Myklebost O, Larsson O (2002) The SYT-SSX1 fusion type of synovial sarcoma is associated with increased expression of cyclin A and D1. A link between t(X;18) (p11.2; q11.2) and the cell cycle machinery. Oncogene 21: 5791-6 Pubmed PDF

Publications 2001

Forus A, Bjerkehagen B, Sirvent N, Meza-Zepeda LA, Coindre J-M, Berner J-M, Myklebost O, Pedeutour F (2001) A well-differentiated liposarcoma with a new type of chromosome 12-derived markers. Cancer Genet Cytogenet 131:13-18 Pubmed PDF

Forus A, D’Angelo A, Henriksen J, Merla G, Mælandsmo GM, Flørenes VA, Olivieri S, Bjerkehagen B, Meza-Zepeda LA, Del Vecchio Blanco F, Muller C, Sanvito F, Kononen J, Nesland JM, Fodstad Ø, Reymond A, Kallioniemi O-P, Arrigoni G, Ballabio A, Myklebost O and Zollo M (2001) Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas – a possible mechanism for altering the nm23-H1 activity. Oncogene, 20:6881-6890 Pubmed PDF

Forus A, Larramendy ML, Meza-Zepeda LA, Bjerkehagen B, GodagerLH, Dahlberg AB, Knuutila S, Myklebost O(2001) Dedifferentiation of awell-differentiated liposarcoma to a highly malignant osteogenic tumouris associated with high-level amplification of 12q14-q22 and gain of1q22. Cancer genet Cytogenet 125:100-111 Pubmed PDF

Forus A, Sørlie T, Børresen-Dale A-L, Myklebost O. (2001) Mikromatriseri kreftforskning: Nå trenger vi ikke å bare lete under gatelyktene!Tidskr. Nor Lægefor. 2498-503 Awarded the journal price for bestpopular article in 2001Paper

Hovig E, Myklebost O, Aamdal S, Smeland EB (2001) Genterapi ved kreft. Tidskr. Nor Lægefor. 121 (4) 482-488Link

Lægreid A, Hovig E, Komorowski J, Forus A, Sandvik AK, Smith-Sørensen B, Beisvåg V, Kristiansen B, Nørsett K, Nygaard V, Støren O, Myklebost O. (2000) DNA mikromatrise – vindu mot tusentals gen. Tidsskr. for Biokjemi24#1:14-20

Meza-Zepeda LA, Berner J-M, Henriksen J, South AP, Pedeutour F,Dahlberg AB, Godager LH, Nizetic D, Forus A, Myklebost O (2001)Ectopic sequences from truncated HMGIC in liposarcomas are derived from various amplified chromosomal regions. Genes Chromosomes & Cancer, 31: 264-273 Pubmed PDF

Sandvik A, Støren O, Nørsett K, Børresen-Dale A-L, Lægreid A, Myklebost O (2001). Måling av genaktivitet med DNA mikromatriser (mikroarray). Molekylære og teknologiske prinsipper. Tidsskr Nor Lægeforen 121: 1225-8 Link

Schutte BC, Carpten JD, Forus A, Gregory SG, Horii A, White PS (2001) Report of the sixth international workshop on human chromosome 1 mapping 2000. Cytogenet Cell Genet, 92:24-40

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Ola Myklebost

Vokste opp på Eiksmarka og Haslum i Bærum, bodde 30 år på Trollåsen i Oppegård, bor nå på Nordnes i Bergen

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